Andrew Koob, PhD
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Andrew Koob, PhD

Assistant Professor


Biology Department

Dana Hall 310C

860.768.5780

koob@hartford.edu



Postdoctoral Fellow   Dartmouth College, UCSD  |   PhD   Purdue University  |   BA   Northwestern University


Research Interests

My research is in the field of cellular neurobiology.  Experiments on human cortical astrocytes isolated in tissue culture are conducted in my lab in an attempt to better understand astrocyte function and nervous system physiology.  In particular, astrocytic differences when exposed to protein forms that accumulate in neurodegenerative disease states compared to control conditions are of interest.  Another line of research are studies on adult astrogenesis in mouse models.  Local astrocyte proliferation is a normal process within the cortex, and determining the function and factors that stimulate or reduce this process could help understand cortical function, astrocyte domains and neural-astrocyte communication.  In association with these studies, we are researching assays to assess cell specific protein levels within nervous tissue.  Cells are excised individually with Laser Microdissection, and protein expression from an aggregate of cell specific tissue can be calculated in order to provide insight into possible astrocyte specific biomarkers. 

Selected Publications

  • Mohn T.C. and Koob A.O. (2015) Adult astrogenesis and the etiology of cortical neurodegeneration. Journal of Experimental Neuroscience. 4;9(Suppl 2):25-34. PMID: 26568684

  • Koob, A.O., Shaked, G., Bender, A., Bisquertt, A., Rockenstein, E., Masliah, E., (2014) Neurogranin binds α-synuclein in human superior temporal cortex and interaction is decreased in Parkinson's disease, Brain Research, 1591:102-110. PMID: 26568684.

  • Bender, A., Desplats, P., Spencer, B., Rockenstein, E., Adame, A., Elstner, M., Laub, C., Mueller, S., Koob, A.O., Mante, M., Pham, E., Klopstock, T., Masliah, E. (2013) TOM-40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson’s disease, PLoS One, 8(4):e62277. PMID:23626796.

  • Koob A.O. (2013) Protein level analysis from specific cell types in heterogeneous tissue.  Recent Advances in Proteomics Research, Nova Science, ed. Ming Li. Series: Protein Biochemistry, Synthesis, Structure and Cellular Function.

  • Koob, A.O., Bruns, L., Prassler, C., Masliah, E., Klopstock, T., and Bender, A., (2012), Protein analysis through Western blot of cells excised individually from human brain and muscle tissue with Laser Capture Microdissection, Analytical Biochemistry, 15;425(2):120-4. PMID:22402104.

  • Koob A.O., Ubhi K., Paulsson J.F., Kelly J., Rockenstein E., Mante M., Adame A. and Masliah E., (2010) Lovastatin ameliorates α-synuclein accumulation and oxidation in transgenic mouse models of α-synucleinopathies. Experimental Neurology 221: 267-274. PMID:19944097.

  • Koob A.O., Paulino A.D. and Masliah E. (2010) GFAP reactivity, apolipoprotein E redistribution and cholesterol reduction in human astrocytes treated with α-synuclein. Neuroscience Letters 469: 11-14. PMID:19932737.

  • Koob A., The Root of Thought (2009) FT Press, Prentice Hall.

  • Koob, A.O., Harris, B.T. and Duhaime A.C. (2008) Cellular genesis in the postnatal piglet, International Journal of Developmental Neuroscience, 26 (6): p. 641-646. PMID:18508228.

  • Bar-On, P., Crews, L., Koob, A.O., Mizuno, H., Adame, A., Spencer, B., Masliah, E. (2008) Statins reduce neuronal α-synuclein aggregation in in vitro models of Parkinson’s disease. Journal of Neurochemistry 105 (5): p. 1656-67. PMID:18248604.

  • Koob, A.O. and Borgens, R.B. (2006) Polyethylene glycol treatment after traumatic brain injury reduces β-amyloid precursor protein accumulation in degenerating axons, Journal of Neuroscience Research 83 (8): p. 1558-1563. PMID:16555285.

  • Koob, A.O., Cirillo, J. and Babbs, C.F. (2006) A novel activity box to determine spatial and temporal rat movement after injury and disease, Journal of Neuroscience Methods 157 (2): p. 330-336. PMID:16735064.

  • Koob, A.O., Duerstock, B.S., Babbs, C.F., Sun, Y., Borgens, R.B. (2005) Intravenous polyethylene glycol inhibits the loss of cerebral cells after traumatic brain injury, Journal of Neurotrauma 22(10): 1092-1111. PMID: 16238486